Abstract

Odo Ikechukwu Ituma*, Dr. Udu-Ibiam, Onyinyechi E., Elom Ugochukwu Okpo,
Igwe Chinenye Precious and Oge Sunday Eze

ABSTRACT

Pathogenic microorganisms that have developed multi-resistance to major classes of antibiotics have become worrisome. The antibacterial activities of the ethyl acetate extracts of citrus maxima obtained via the agar well diffusion method against multidrug -resistant Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus from clinical samples were examined. The inhibition zone diameter (IZD) of the plant extract against Pseudomonas aeruginosa was greatest at 50 mg/ml and 12.5 mg/ml, resulting in an inhibition zone diameter of 12 mm, followed by that of Staphylococcus aureus at 100 mg/ml and 25 mg/ml at 8 mm and that of Escherichia coli at 100 mg/ml and 50 mg/ml. Ciprofloxacin (positive control) was effective at all concentrations, but no activity was detected in the sterile distilled water used (negative control). The minimum inhibitory concentration and maximum bactericidal concentration results revealed that Pseudomonas aeruginosa was highly susceptible to the plant extract. This result confirmed the efficacy of the plant in inhibiting bacterial growth.

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